Data-driven Process Systems Engineering Lab
Relevant Publications
Methods and Tools for Design Space Indentification in Pharmaceutical Development
Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture 2018
The need for a more structured approach to process development has been recently identified in the pharmaceutical industry in order to consistently guarantee quality and value to processes and products. The concept of design space (DS) is a key aspect…
Feasibility analysis of black-box processes using an adaptive sampling kriging-based method
Computers & Chemical Engineering 2012
This paper presents a new approach for performing feasibility analysis over a multivariate factor space when the explicit form of a process model is lacking or when its evaluation is expensive. Specifically, two issues are addressed: feasibility evaluation of black-box…
Design Space of pharmaceutical processes using data-driven based methods
Journal of Pharmaceutical Innovation 2010
Introduction The identification and graphical representation of process design space are critical in locating not only feasible but also optimum operating variable ranges and design configurations. In this work, the mapping of the design space of pharmaceutical processes is achieved…
Relevant Presentations
Data-Centric Optimization: Methods and Applications
2015 AIChE Annual Meeting in Exhibit Hall 1 (Salt Palace Convention Center)
November 08, 2015
As an engineering community we have been working towards developing detailed mathematical simulation models which accurately capture the behavior of complex systems. This trend is reinforced by our drive to couple multiscale information which ranges from the atomistic and molecular…
Design Space of pharmaceutical processes using data-driven based methods
AIChE Annual Meeting in Salt Lake City
November 08, 2010
The identification and graphical representation of process design space is very critical in locating not only feasible but also optimum operating variable ranges and design configurations. Design space of a process is the area of the parametric space within which…
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