Research

Design Space of pharmaceutical processes using data-driven based methods

AIChE Annual Meeting in Salt Lake City

November 08, 2010

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

The identification and graphical representation of process design space is very critical in locating not only feasible but also optimum operating variable ranges and design configurations. Design space of a process is the area of the parametric space within which…

Predictive modeling of pharmaceutical processes with missing and noisy data

2009 AIChE Annual Meeting in Nashville

November 12, 2009

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

Current trends in pharmaceutical product development focus on the fundamental understanding and characterization of all process unit operations, which will lead to the development of predictive models in order to minimize the variability in product performance. The pharmaceutical industry is…

Simulation Based Optimization of Expensive Flowsheet Models for Continuous Pharmaceutical Manufacturing

2011 AIChE Annual Meeting in Minneapolis

October 20, 2011

F. Boukouvala F.J. Muzzio M.G. Ierapetritou

The main purpose of this work is to develop an efficient strategy for simulation-based design and optimization for a pharmaceutical tablet manufacturing process. Simulation-based optimization is a research area that is currently attracting a lot of attention in many industrial…