Reduced order Discrete Element Method (DEM) modeling

Chemical Engineering Science 2013

F. Boukouvala F.J. Muzzio M.G. Ierapetritou Y. Gao

Reduced-order modeling (ROM) techniques are playing a very significant role in the recent literature bridging the gap between computationally expensive simulators and their application in optimization and control of distributed parameter systems. In modeling of solid-based processes, Discrete Element Method…

Improving continuous powder blending performance using Projection to Latent Structures regression

Journal of Pharmaceutical Innovation 2013

Y. Gao F. Boukouvala W. Englisch W. Meng F.J. Muzzio M.G. Ierapetritou

Purpose There has been increasing interest in the last few years especially within the pharmaceutical industry towards continuous powder blending. In this paper, the effects of different design and operating parameters are investigated, which include blade speed, shaft angle, weir…

Computer-Aided Flowsheet Simulation of a Pharmaceutical Tablet Manufacturing Process Incorporating Wet Granulation

Journal of Pharmaceutical Innovation 2013

A. Chaudhuri F. Boukouvala L. Mioduszewski M. Sen M.G. Ierapetritou R. Ramachandran R. Zhou

In this work, a dynamic flowsheet model for the production of pharmaceutical tablets through a continuous wet granulation process is developed. The unit operation models which are integrated to compose the process line form a hybrid configuration which is comprised…

An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process

Computers & Chemical Engineering 2012

F. Boukouvala F.J. Muzzio M.G. Ierapetritou R. Ramachandran V. Niotis

Manufacturing of powder-based products is a focus of increasing research in the recent years. The main reason is the lack of predictive process models connecting process parameters and material properties to product quality attributes. Moreover, the trend towards continuous manufacturing…

Improving coating uniformity in pharmaceutical tablets: A QbD approach

AAPS PharmSciTech 2012

A. Dubey F. Boukouvala G. Keyvan R. Hsia K. Saranteas D. Brone M.G. Ierapetritou F.J. Muzzio

A combination of analytical and statistical methods is used to improve a tablet coating process guided by quality by design (QbD) principles. A solid dosage form product was found to intermittently exhibit bad taste. A suspected cause was the variability…